Corpus ID: 92991338

The Oligosaccharide Galactose-α1 , 3-Galactose and the α-Gal Syndrome : Insights from an Epitope that is Causal in Immunoglobulin E-Mediated Immediate and Delayed Anaphylaxis

@inproceedings{Wilson2018TheOG,
  title={The Oligosaccharide Galactose-$\alpha$1 , 3-Galactose and the $\alpha$-Gal Syndrome : Insights from an Epitope that is Causal in Immunoglobulin E-Mediated Immediate and Delayed Anaphylaxis},
  author={Jeffrey M Wilson and T. Platts-Mills},
  year={2018}
}
Galactose-α-1,3-galactose (α-Gal) is an oligosaccharide that was first described as a cause of immunoglobulin E-mediated anaphylaxis in cases of first-in-man reactions to the monoclonal antibody cetuximab. Soon thereafter, immunoglobulin E antibodies to this epitope were linked with anaphylactic episodes to mammalian meat, which had a characteristic delay of ~3-6 hours. The ‘α-Gal syndrome’ is now recognised globally as a significant form of food allergy, albeit with regional variation, which… Expand

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