The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

  title={The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells},
  author={Yuin-Han Loh and Qiang Wu and Joon-Lin Chew and Vinsensius B. Vega and Weiwei Zhang and Xi Chen and Guillaume Bourque and Joshy George and Bernard Leong and Jun Liu and Kee-Yew Wong and Ken Wing Kin Sung and Charlie Wah Heng Lee and Xiaodong Zhao and Kuo-Ping Chiu and Leonard Lipovich and Vladimir A. Kuznetsov and Paul Robson and Lawrence Walter Stanton and Chia-Lin Wei and Yijun Ruan and Bing Lim and Huck-Hui Ng},
  journal={Nature Genetics},
Oct4 and Nanog are transcription factors required to maintain the pluripotency and self-renewal of embryonic stem (ES) cells. Using the chromatin immunoprecipitation paired-end ditags method, we mapped the binding sites of these factors in the mouse ES cell genome. We identified 1,083 and 3,006 high-confidence binding sites for Oct4 and Nanog, respectively. Comparative location analyses indicated that Oct4 and Nanog overlap substantially in their targets, and they are bound to genes in… CONTINUE READING
Highly Influential
This paper has highly influenced 136 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 6 times over the past 90 days. VIEW TWEETS
1,095 Citations
52 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 1,095 extracted citations


Publications referenced by this paper.
Showing 1-10 of 52 references

A high-resolution map of active promoters in the human genome

  • Kim, T.H
  • Nature 436,
  • 2005

Similar Papers

Loading similar papers…