The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

@article{Loh2006TheOA,
  title={The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells},
  author={Yuin-Han Loh and Qiang Wu and Joon-Lin Chew and Vinsensius B. Vega and Weiwei Zhang and Xi Chen and Guillaume Bourque and Joshy George and Bernard Leong and Jun Liu and Kee-Yew Wong and Ken Wing Kin Sung and Charlie Wah Heng Lee and Xiaodong Zhao and Kuo-Ping Chiu and Leonard Lipovich and Vladimir A. Kuznetsov and Paul Robson and Lawrence Walter Stanton and Chia-Lin Wei and Yijun Ruan and Bing Lim and Huck-Hui Ng},
  journal={Nature Genetics},
  year={2006},
  volume={38},
  pages={431-440}
}
Oct4 and Nanog are transcription factors required to maintain the pluripotency and self-renewal of embryonic stem (ES) cells. Using the chromatin immunoprecipitation paired-end ditags method, we mapped the binding sites of these factors in the mouse ES cell genome. We identified 1,083 and 3,006 high-confidence binding sites for Oct4 and Nanog, respectively. Comparative location analyses indicated that Oct4 and Nanog overlap substantially in their targets, and they are bound to genes in… CONTINUE READING
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