The OSIRIS Weight of Evidence approach: ITS mutagenicity and ITS carcinogenicity.

@article{Buist2013TheOW,
  title={The OSIRIS Weight of Evidence approach: ITS mutagenicity and ITS carcinogenicity.},
  author={Harrie E Buist and Tom Aldenberg and Monika Batke and Sylvia E. Escher and Rinke H Klein Entink and Ralph K{\"u}hne and Hans Marquart and Eduard Paun{\'e} and Emiel Rorije and Gerrit Sch{\"u}{\"u}rmann and Dinant E D Kroese},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2013},
  volume={67 2},
  pages={170-81}
}
Risk assessment of chemicals usually implies data evaluation of in vivo tests in rodents to conclude on their hazards. The FP7 European project OSIRIS has developed integrated testing strategies (ITS) for relevant toxicological endpoints to avoid unnecessary animal testing and thus to reduce time and costs. This paper describes the implementation of ITS mutagenicity and carcinogenicity in the public OSIRIS webtool. The data requirements of REACH formed the basis for these ITS. The main goal was… CONTINUE READING

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