The ORF1 gene located on the class-1-integron-associated gene cassette actually represents a novel fosfomycin resistance determinant.


The class 1 integrons are genetic elements capable of integrating gene cassettes by a site-specific recombination mechanism (1). Gene cassettes are mobile units composed of a gene, most often an antibiotic resistance gene, and a recombination site, the 59-base element (1). We have previously characterized a class 1 integron containing a VIM-2-type metallo… (More)


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