The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny.

@article{Shafi2000TheOT,
  title={The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny.},
  author={R Shafi and Sai Prasad N Iyer and Lesley G Ellies and Niall O'Donnell and Kurt W. Marek and D K C Chui and Gerald W. Hart and Jamey D Marth},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 11},
  pages={5735-9}
}
Nuclear and cytoplasmic protein glycosylation is a widespread and reversible posttranslational modification in eukaryotic cells. Intracellular glycosylation by the addition of N-acetylglucosamine (GlcNAc) to serine and threonine is catalyzed by the O-GlcNAc transferase (OGT). This "O-GlcNAcylation" of intracellular proteins can occur on phosphorylation sites, and has been implicated in controlling gene transcription, neurofilament assembly, and the emergence of diabetes and neurologic disease… CONTINUE READING
Highly Influential
This paper has highly influenced 16 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS