The Nup153-Nup50 protein interface and its role in nuclear import.

  title={The Nup153-Nup50 protein interface and its role in nuclear import.},
  author={Masaki Makise and Douglas R Mackay and Suzanne W Elgort and Sunita S Shankaran and Stephen A. Adam and Katharine S. Ullman},
  journal={The Journal of biological chemistry},
  volume={287 46},
Interactions between Nup50 and soluble transport factors underlie the efficiency of certain nucleocytoplasmic transport pathways. The platform on which these interactions take place is important to building a complete understanding of nucleocytoplasmic trafficking. Nup153 is the nucleoporin that provides this scaffold for Nup50. Here, we have delineated requirements for the interaction between Nup153 and Nup50, revealing a dual interface. An interaction between Nup50 and a region in the unique… CONTINUE READING


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