The Nuclear Receptor Peroxisome Proliferator-Activated Receptor-α Mediates the Anti-Inflammatory Actions of Palmitoylethanolamide

@article{LoVerme2005TheNR,
  title={The Nuclear Receptor Peroxisome Proliferator-Activated Receptor-$\alpha$ Mediates the Anti-Inflammatory Actions of Palmitoylethanolamide},
  author={Jesse Lo Verme and Jin Fu and Giuseppe Astarita and G. La Rana and Roberto Russo and Antonio Calignano and Daniele Piomelli},
  journal={Molecular Pharmacology},
  year={2005},
  volume={67},
  pages={15 - 19}
}
Palmitoylethanolamide (PEA), the naturally occurring amide of palmitic acid and ethanolamine, reduces pain and inflammation through an as-yet-uncharacterized mechanism. Here, we identify the nuclear receptor peroxisome proliferator-activated receptor-α (PPAR-α) as the molecular target responsible for the anti-inflammatory properties of PEA. PEA selectively activates PPAR-α in vitro with an EC50 value of 3.1 ± 0.4 μM and induces the expression of PPAR-α mRNA when applied topically to mouse skin… 
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