The Nuclear Receptor Peroxisome Proliferator-Activated Receptor-α Mediates the Anti-Inflammatory Actions of Palmitoylethanolamide

@article{Verme2005TheNR,
  title={The Nuclear Receptor Peroxisome Proliferator-Activated Receptor-α Mediates the Anti-Inflammatory Actions of Palmitoylethanolamide},
  author={J. Lo Verme and J. Fu and G. Astarita and G. La Rana and R. Russo and A. Calignano and D. Piomelli},
  journal={Molecular Pharmacology},
  year={2005},
  volume={67},
  pages={15 - 19}
}
Palmitoylethanolamide (PEA), the naturally occurring amide of palmitic acid and ethanolamine, reduces pain and inflammation through an as-yet-uncharacterized mechanism. Here, we identify the nuclear receptor peroxisome proliferator-activated receptor-α (PPAR-α) as the molecular target responsible for the anti-inflammatory properties of PEA. PEA selectively activates PPAR-α in vitro with an EC50 value of 3.1 ± 0.4 μM and induces the expression of PPAR-α mRNA when applied topically to mouse skin… Expand
665 Citations
Oleamide activates peroxisome proliferator-activated receptor gamma (PPARγ) in vitro
  • 16
Rapid Broad-Spectrum Analgesia through Activation of Peroxisome Proliferator-Activated Receptor-α
  • 276
Nuclear Control of the Inflammatory Response in Mammals by Peroxisome Proliferator-Activated Receptors
  • 65
  • PDF
The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver.
  • 53
  • PDF
Acute Intracerebroventricular Administration of Palmitoylethanolamide, an Endogenous Peroxisome Proliferator-Activated Receptor-α Agonist, Modulates Carrageenan-Induced Paw Edema in Mice
  • 124
Peroxisome Proliferator-Activated Receptors: Experimental Targeting for the Treatment of Inflammatory Bowel Diseases
  • 1
Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-kappaB nuclear signalling in dorsal root ganglia.
  • 108
Peroxisome Proliferator-Activated Receptor α Mediates Acute Effects of Palmitoylethanolamide on Sensory Neurons
  • 54
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 49 REFERENCES
Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α
  • 914
  • PDF
The mechanisms of action of PPARs.
  • 2,151
  • PDF
Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation
  • 847
Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models.
  • 165
  • Highly Influential
Effects of cannabinoid receptor ligands on LPS-induced pulmonary inflammation in mice.
  • 118
Peroxisome proliferator-activated receptor α target genes
  • 689
The palmitoylethanolamide family: a new class of anti-inflammatory agents?
  • 257
  • PDF
Therapeutic effect of the endogenous fatty acid amide, palmitoylethanolamide, in rat acute inflammation: inhibition of nitric oxide and cyclo‐oxygenase systems
  • 117
  • Highly Influential
...
1
2
3
4
5
...