The Nuclear Receptor HIZR-1 Uses Zinc as a Ligand to Mediate Homeostasis in Response to High Zinc

@inproceedings{Warnhoff2017TheNR,
  title={The Nuclear Receptor HIZR-1 Uses Zinc as a Ligand to Mediate Homeostasis in Response to High Zinc},
  author={Kurt Warnhoff and Hyun Cheol Roh and Zuzana Kocsisova and Chieh-Hsiang Tan and Andrew David Morrison and Damari Croswell and Daniel L. Schneider and Kerry Kornfeld},
  booktitle={PLoS biology},
  year={2017}
}
Nuclear receptors were originally defined as endocrine sensors in humans, leading to the identification of the nuclear receptor superfamily. Despite intensive efforts, most nuclear receptors have no known ligand, suggesting new ligand classes remain to be discovered. Furthermore, nuclear receptors are encoded in the genomes of primitive organisms that lack… CONTINUE READING