The Nuclear Receptor DHR3 Modulates dS6 Kinase–Dependent Growth in Drosophila

@inproceedings{Montagne2010TheNR,
  title={The Nuclear Receptor DHR3 Modulates dS6 Kinase–Dependent Growth in Drosophila},
  author={Jacques Montagne and Caroline Lecerf and Jean-Philippe Parvy and Janis M. Bennion and Thomas Radimerski and M Laure Ruhf and Fr{\'e}d{\'e}ric Zilbermann and Nicole Vouilloz and Hugo Stocker and Ernst Hafen and Sara C. Kozma and George Thomas},
  booktitle={PLoS genetics},
  year={2010}
}
S6 kinases (S6Ks) act to integrate nutrient and insulin signaling pathways and, as such, function as positive effectors in cell growth and organismal development. However, they also have been shown to play a key role in limiting insulin signaling and in mediating the autophagic response. To identify novel regulators of S6K signaling, we have used a Drosophila-based, sensitized, gain-of-function genetic screen. Unexpectedly, one of the strongest enhancers to emerge from this screen was the… CONTINUE READING