The Nuclear Effector of Wnt-Signaling, Tcf1, Functions as a T-Cell–Specific Tumor Suppressor for Development of Lymphomas

@inproceedings{Tiemessen2012TheNE,
  title={The Nuclear Effector of Wnt-Signaling, Tcf1, Functions as a T-Cell–Specific Tumor Suppressor for Development of Lymphomas},
  author={Machteld M. Tiemessen and Miranda R. M. Baert and Tom Schonewille and Martijn H. Brugman and Farbod Famili and Daniela C. F. Salvatori and Jules P P Meijerink and Ugur Ozbek and Hans Clevers and Jacques J M van Dongen and Frank J. T. Staal},
  booktitle={PLoS biology},
  year={2012}
}
The HMG-box factor Tcf1 is required during T-cell development in the thymus and mediates the nuclear response to Wnt signals. Tcf1(-/-) mice have previously been characterized and show developmental blocks at the CD4-CD8- double negative (DN) to CD4+CD8+ double positive transition. Due to the blocks in T-cell development, Tcf1(-/-) mice normally have a very small thymus. Unexpectedly, a large proportion of Tcf1(-/-) mice spontaneously develop thymic lymphomas with 50% of mice developing a… CONTINUE READING