The Nuclear Effector of Wnt-Signaling, Tcf1, Functions as a T-Cell–Specific Tumor Suppressor for Development of Lymphomas

Abstract

The HMG-box factor Tcf1 is required during T-cell development in the thymus and mediates the nuclear response to Wnt signals. Tcf1(-/-) mice have previously been characterized and show developmental blocks at the CD4-CD8- double negative (DN) to CD4+CD8+ double positive transition. Due to the blocks in T-cell development, Tcf1(-/-) mice normally have a very… (More)
DOI: 10.1371/journal.pbio.1001430

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@inproceedings{Tiemessen2012TheNE, title={The Nuclear Effector of Wnt-Signaling, Tcf1, Functions as a T-Cell–Specific Tumor Suppressor for Development of Lymphomas}, author={Machteld M. Tiemessen and Miranda R. M. Baert and Tom Schonewille and Martijn H. Brugman and Farbod Famili and Daniela C. F. Salvatori and Jules P P Meijerink and Uğur Ozbek and Hans Clevers and Jacques J M van Dongen and Frank J. T. Staal}, booktitle={PLoS biology}, year={2012} }