The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration.

@article{Johnson2008TheNP,
  title={The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration.},
  author={Jeffrey A. Johnson and Delinda A. Johnson and Andrew D Kraft and Marcus J. Calkins and Rebekah J. Jakel and Marcelo R. Vargas and Pei-Chun Chen},
  journal={Annals of the New York Academy of Sciences},
  year={2008},
  volume={1147},
  pages={61-9}
}
Transcriptional activation of protective genes is mediated by a cis-acting element called the antioxidant responsive element (ARE). The transcription factor Nrf2 (NF-E2-related factor 2) binds to the ARE. Activation of this pathway protects cells from oxidative stress-induced cell death. Increased oxidative stress is associated with neuronal cell death during the pathogenesis of multiple chronic neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease… CONTINUE READING
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