The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance

  title={The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance},
  author={Anna Lisa Furfaro and Nicola Traverso and Cinzia Domenicotti and Sabrina Piras and Alessandro Moretta and Umberto Maria Marinari and Maria Adelaide Pronzato and Mariapaola Nitti},
  booktitle={Oxidative medicine and cellular longevity},
The transcription factor, nuclear factor erythroid 2 p45-related factor 2 (Nrf2), acts as a sensor of oxidative or electrophilic stresses and plays a pivotal role in redox homeostasis. Oxidative or electrophilic agents cause a conformational change in the Nrf2 inhibitory protein Keap1 inducing the nuclear translocation of the transcription factor which, through its binding to the antioxidant/electrophilic response element (ARE/EpRE), regulates the expression of antioxidant and detoxifying genes… CONTINUE READING
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