The Nramp1 protein and its role in resistance to infection and macrophage function.

@article{CanonneHergaux1999TheNP,
  title={The Nramp1 protein and its role in resistance to infection and macrophage function.},
  author={François Canonne-Hergaux and Samantha Gruenheid and Gregory Govoni and Philippe Gros},
  journal={Proceedings of the Association of American Physicians},
  year={1999},
  volume={111 4},
  pages={283-9}
}
Susceptibility to infectious diseases is under genetic control in humans. Animal models provide an ideal tool to study the genetic component of susceptibility and to identify candidate genes that can then be tested for association or linkage studies in human populations from endemic areas of disease. The Nramp1 gene was isolated by positional cloning the host resistance locus Bcg/Ity/Lsh, and mutations at this locus impair the resistance of mice to infections with intracellular parasites, such… CONTINUE READING
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