The Nox family of NADPH oxidases: friend or foe of the vascular system?

  title={The Nox family of NADPH oxidases: friend or foe of the vascular system?},
  author={Ina Takac and Katrin Schroeder and Ralf Peter Brandes},
  journal={Current hypertension reports},
  volume={14 1},
NADPH (nicotinamide adenine dinucleotide phosphate) oxidases are important sources of reactive oxygen species (ROS). In the vascular system, ROS can have both beneficial and detrimental effects. Under physiologic conditions, ROS are involved in signaling pathways that regulate vascular tone as well as cellular processes like proliferation, migration and differentiation. However, high doses of ROS, which are produced after induction or activation of NADPH oxidases in response to cardiovascular… CONTINUE READING


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