The Novel Retinoid, 9cUAB30, Inhibits Telomerase and Induces Apoptosis in HL60 Cells.

@article{Love2008TheNR,
  title={The Novel Retinoid, 9cUAB30, Inhibits Telomerase and Induces Apoptosis in HL60 Cells.},
  author={William K Love and J. DeAngelis and Joel B Berletch and Sharla M O Phipps and Lucy G. Andrews and Wayne J. Brouillette and Donald D. Muccio and Trygve O. Tollefsbol},
  journal={Translational oncology},
  year={2008},
  volume={1 3},
  pages={148-52}
}
Telomerase, a ribonucleoprotein important to neoplastic immortality, is up-regulated in approximately 85% of cancers, including leukemias. In this study, 9cUAB30, a novel retinoic acid, resulted in differentiation of HL60 leukemia cells as indicated by morphologic changes characteristic of granulocytes. It also caused a down-regulation of hTERT gene expression and a decrease in telomerase activity. Telomerase inhibition was followed by loss of proliferative capacity, induction of apoptosis, and… CONTINUE READING