The Novel Contribution of the ER/SR Ca2+ Sensor STIM1 to Cardiac Function and Metabolism

@article{Collins2015TheNC,
  title={The Novel Contribution of the ER/SR Ca2+ Sensor STIM1 to Cardiac Function and Metabolism},
  author={Helen E Collins and Betty M Pat and Silvio Litovsky and Martin E. Young and John C. Chatham},
  journal={The FASEB Journal},
  year={2015},
  volume={29}
}
Store‐operated Ca2+ entry (SOCE) occurs following ER/SR Ca2+ depletion and is mediated by the ER/SR Ca2+ sensor, Stromal Interaction molecule 1 (STIM1) and plasma membrane Orai1 channels. The role of SOCE in the heart has not been widely explored; however, we recently reported that cardiomyocyte restricted deletion of STIM1 (crSTIM1‐KO) lead to increased ER stress, mitochondrial dysfunction, reduced cardiac function and the development of a dilated cardiomyopathy. Since Ca2+ plays a key role in…