The Notch2–Jagged1 interaction mediates stem cell factor signaling in erythropoiesis

@article{Zeuner2011TheNI,
  title={The Notch2–Jagged1 interaction mediates stem cell factor signaling in erythropoiesis},
  author={Ann Zeuner and Federica Francescangeli and Mariarosaria Del Signore and Mary A Venneri and Francesca Pedini and Nadia Felli and Alfredo Pagliuca and Concetta Conticello and Raffaella De Maria},
  journal={Cell Death and Differentiation},
  year={2011},
  volume={18},
  pages={371-380}
}
Stem cell factor (SCF), the ligand for the c-kit receptor, is essential for the production of red blood cells during development and stress erythropoiesis. SCF promotes erythroblast proliferation and survival, while delaying erythroid differentiation through mechanisms that are largely unknown. In cultures of primary human differentiating erythroblasts, we found that SCF induces an increase in the expression of Notch2, a member of the Notch family implicated in the control of cell growth and… CONTINUE READING
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