The Notch1/cyclooxygenase-2/Snail/E-cadherin pathway is associated with hypoxia-induced hepatocellular carcinoma cell invasion and migration.

@article{Yu2013TheNP,
  title={The Notch1/cyclooxygenase-2/Snail/E-cadherin pathway is associated with hypoxia-induced hepatocellular carcinoma cell invasion and migration.},
  author={Ling-xiang Yu and Liang Zhou and Mo Li and Zhi-wei Li and De-sheng Wang and Shaogeng Zhang},
  journal={Oncology reports},
  year={2013},
  volume={29 1},
  pages={
          362-70
        }
}
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide; however, the prognosis of HCC patients remains poor. This poor prognosis is mainly attributed to the high rate of intrahepatic and distant metastasis. HCC often occurs in a hypoxic environment and hypoxia can activate metastatic programs, ultimately leading to tumor recurrence or metastasis. Thus, the discovery and subsequent development of novel agents to… 
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Citation Type

Citation Type

COX-2 regulates Snail expression in gastric cancer via the Notch1 signaling pathway.
TLDR
COX‑2 inversely regulated notch1 in GC and partially depended on the Notch1 signalling pathway in altering the expression of Snail, which was found to be related to the depth of invasion and TNM staging.
Upregulation of PP2Ac predicts poor prognosis and contributes to aggressiveness in hepatocellular carcinoma
TLDR
Gene expression profiling analysis showed that PP2Ac downregulation modulated the expression of numerous genes involved in cell cycle and apoptosis regulation, and PP2 Ac may represent a potential therapeutic target for HCC.
Snail inhibits Notch1 intracellular domain mediated transcriptional activation via competing with MAML1.
Transforming growth factor-β1 induces bronchial epithelial cells to mesenchymal transition by activating the Snail pathway and promotes airway remodeling in asthma.
TLDR
The results indicated that myofibroblasts deriving from bronchial epithelial cells via EMT may contribute to peribronchial fibrosis and that Snail may be an important factor in this phenomenon.
Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia.
TLDR
The potential role of hypoxia, a major feature of most solid tumors, within the tumor microenvironment and how it contributes to immune resistance and immune suppression/tolerance and can be detrimental to antitumor effector cell functions is outlined.
Sodium taurocholate cotransporting polypeptide mediates dual actions of deoxycholic acid in human hepatocellular carcinoma cells: enhanced apoptosis versus growth stimulation
TLDR
Hydrophobic bile acid offers therapeutic potential for patients with advanced HCC via different mechanisms depending on NTCP expression levels within the tumor.
Novel bioresponsive drug eluting microspheres to enhance chemoembolisation therapy
TLDR
An avenue for improvement would be the development of novel bioresponsive DEB that are able to react to the conditions of hypoxia to overcome chemoresistance associated with the tumour cells.
Mechanisms of Invasion and Metastasis: Cell Migration and Chemotaxis

References

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TLDR
Results suggest that activation of Notch1 signal pathway promotes progression of gastric cancer, at least in part through COX-2.
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TLDR
It is shown that overexpression of Notch1 was able to inhibit the growth of HCC cells in vitro and in vivo, and suggest that Notch 1 signaling may participate in the development of H CC cells, affecting multiple pathways that control both cell proliferation and apoptosis.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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