The Notch signalling system: recent insights into the complexity of a conserved pathway

@article{Guruharsha2012TheNS,
  title={The Notch signalling system: recent insights into the complexity of a conserved pathway},
  author={K. G. Guruharsha and Mark W. Kankel and S. Artavanis-Tsakonas},
  journal={Nature Reviews Genetics},
  year={2012},
  volume={13},
  pages={654-666}
}
Notch signalling links the fate of one cell to that of an immediate neighbour and consequently controls differentiation, proliferation and apoptotic events in multiple metazoan tissues. Perturbations in this pathway activity have been linked to several human genetic disorders and cancers. Recent genome-scale studies in Drosophila melanogaster have revealed an extraordinarily complex network of genes that can affect Notch activity. This highly interconnected network contrasts our traditional… CONTINUE READING
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