The Notch-responsive transcription factor Hes-1 attenuates osteocalcin promoter activity in osteoblastic cells.

Abstract

Notch signaling plays a key role in osteoblast differentiation. A major transcriptional downstream regulator of this pathway is the helix-loop-helix (HLH) transcription factor Hairy/Enhancer of Split 1 (Hes-1). Here we investigated the function of Hes-1 in osteoblastic cells. Endogenous Hes-1 gene expression decreases during progression of bone cell… (More)
DOI: 10.1002/jcb.22299

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