The Notch ligand DLL4 specifically marks human hematoendothelial progenitors and regulates their hematopoietic fate

@article{Aylln2015TheNL,
  title={The Notch ligand DLL4 specifically marks human hematoendothelial progenitors and regulates their hematopoietic fate},
  author={Ver{\'o}nica Ayll{\'o}n and Clara Bueno and Ver{\'o}nica Ramos-Mej{\'i}a and Oscar Navarro-Montero and Christopher Prieto and Pedro J Real and Tamara Romero and Mar{\'i}a J. Garc{\'i}a-Le{\'o}n and Mar{\'i}a L Toribio and Anna Bigas and P. J. Men{\'e}ndez},
  journal={Leukemia},
  year={2015},
  volume={29},
  pages={1741-1753}
}
Notch signaling is essential for definitive hematopoiesis, but its role in human embryonic hematopoiesis is largely unknown. We show that in hESCs the expression of the Notch ligand DLL4 is induced during hematopoietic differentiation. We found that DLL4 is only expressed in a sub-population of bipotent hematoendothelial progenitors (HEPs) and segregates their hematopoietic versus endothelial potential. We demonstrate at the clonal level and through transcriptome analyses that DLL4high HEPs are… CONTINUE READING
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