The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids

@inproceedings{Kessler2015TheNA,
  title={The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids},
  author={Mirjana Kessler and Karen Hoffmann and V Brinkmann and Oliver Thieck and Susan Jackisch and Benjamin Toelle and Hilmar Berger and Hans-Joachim Mollenkopf and Mandy Mangler and Jalid Sehouli and C. Fotopoulou and Thomas F. Meyer},
  booktitle={Nature communications},
  year={2015}
}
The epithelial lining of the fallopian tube is of critical importance for human reproduction and has been implicated as a site of origin of high-grade serous ovarian cancer. Here we report on the establishment of long-term, stable 3D organoid cultures from human fallopian tubes, indicative of the presence of adult stem cells. We show that single epithelial stem cells in vitro can give rise to differentiated organoids containing ciliated and secretory cells. Continuous growth and differentiation… CONTINUE READING