The Norton Lecture: a review of the oligodendrocyte in the multiple sclerosis lesion.

@article{Raine1997TheNL,
  title={The Norton Lecture: a review of the oligodendrocyte in the multiple sclerosis lesion.},
  author={Cedric S Raine},
  journal={Journal of neuroimmunology},
  year={1997},
  volume={77 2},
  pages={135-52}
}
The mechanisms involved in the elimination of oligodendrocytes and myelin from the demyelinated plaque of multiple sclerosis (MS) are inextricably intertwined and yet most investigations tend to consider them separately. This short review revisits the problem of oligodendrocyte pathology in MS and attempts to put the topic into perspective by examining the numerous immunologically-active molecules associated with the oligodendrocyte, some, but not all, cross-reactive with myelin. The consensus… CONTINUE READING
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