The Northwick Park Study of First Episodes of Schizophrenia

@article{Johnstone1986TheNP,
  title={The Northwick Park Study of First Episodes of Schizophrenia},
  author={Eve C. Johnstone and Timothy J. Crow and A. L. Johnson and J. Fiona Macmillan},
  journal={British Journal of Psychiatry},
  year={1986},
  volume={148},
  pages={115 - 120}
}
Patients referred over 28 months from nine medical centres for a trial of prophylactic neuroleptic medication following first episodes of schizophrenic illness (462) were assessed with the Present State Examination, WHO scales for disability, past history, and socio-demographic factors, and a rating of disturbed behaviour; 253 fulfilled the study criteria; of the 209 who did not, 54 did not meet the diagnostic criteria, 65 had a history of a previous episode, and in 15 the psychotic illness was… 
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386 Citations
Highly Influential Citations
6
Background Citations
80
Methods Citations
1
Results Citations
11

386 Citations

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Of 253 patients in their first schizophrenic episode, 52 behaved in a way threatening to the lives of others before their admission to hospital, and life-threatening behaviour was more common where the patient had been ill for longer, and where there were delusions of being poisoned.
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Methodological improvements in first-admission research are suggested, including separating the analyses of first-episode patients from those with past psychotic experiences, employing longitudinal methods for deriving diagnosis, and enlarging the samples either by multisite or multicenter collaborations or by pooling data across studies.
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Early course parameters of a Norwegian first-episode sample demonstrated strong gender differences, with male patients having significantly higher frequency of single marital status, lower educational status, schizophrenia, early age at onset, and lower Global Assessment of Functioning scores the last year before hospitalization.
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