The Normal and Malignant Mammary Gland: A Fresh Look with ERβ Onboard

  title={The Normal and Malignant Mammary Gland: A Fresh Look with ER$\beta$ Onboard},
  author={Margaret Warner and Shigehira Saji and Jan-{\AA}ke Gustafsson},
  journal={Journal of Mammary Gland Biology and Neoplasia},
Estrogens are important for the development and function of the normal mammary gland as well as for development of mammary cancer. The frontline therapy for treatment of estrogen receptor (ERα)4 positive breast cancer is antiestrogens. A second estrogen receptor (ERβ) is also expressed in the breast but it has not been measured because it is not detected by the immunoassays used to detect ERα. In many cell systems ERβ has actions which are opposite to those of ERα and this finding has raised… 
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