The Normal Function of a Speciation Gene, Odysseus, and Its Hybrid Sterility Effect

@article{Sun2004TheNF,
  title={The Normal Function of a Speciation Gene, Odysseus, and Its Hybrid Sterility Effect},
  author={Shan Sun and C T Ting and Chung-I Wu},
  journal={Science},
  year={2004},
  volume={305},
  pages={81 - 83}
}
To understand how postmating isolation is connected to the normal process of species divergence and why hybrid male sterility is often the first sign of speciation, we analyzed the Odysseus (OdsH) gene of hybrid male sterility in Drosophila. We carried out expression analysis, transgenic study, and gene knockout. The combined evidence suggests that the sterility phenotype represents a novel manifestation of the gene function rather than the reduction or loss of the normal one. The gene knockout… Expand
Gene duplication and speciation in Drosophila: evidence from the Odysseus locus.
  • C. Ting, S. Tsaur, +4 authors Chung-I Wu
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
TLDR
It is shown that a hybrid-male sterility gene, Odysseus (OdsH), arose by gene duplication in the Drosophila genome, and it is suggested that duplicated genes that have yet to evolve a stable function at the time of speciation may be candidates for "speciation genes," which is broadly defined as genes that contribute to differential adaptation between species. Expand
Adaptive loss of an old duplicated gene during incipient speciation.
TLDR
Results suggest that ds2 is one of the genes responsible for adaptive divergence of the Z and M races of D. melanogaster, and has been maintained in the Drosophila genus for at least 40 Myr without any sign of adaptive change. Expand
Why hybrid males are sterile in Drosophila
TLDR
The resurgence of interest in hybrid male sterility and the use of Drosophila as a model organism for such study warrant a comprehensive review on this topic to facilitate better understanding of this subject. Expand
The genetic basis of reproductive isolation: Insights from Drosophila
  • H. A. Orr
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005
TLDR
It is concluded that speciation genes correspond to ordinary loci having normal functions within species, although a role in transcriptional regulation could prove particularly common. Expand
Altered Heterochromatin Binding by a Hybrid Sterility Protein in Drosophila Sibling Species
TLDR
It is shown that the hybrid male sterility gene Odysseus-site homeobox (OdsH) encodes a protein that localizes to evolutionarily dynamic loci within heterochromatin and leads to their decondensation, revealing that rapid heterochromeatin evolution affects the onset of hybrid sterility. Expand
Strong Purifying Selection on the Odysseus Gene in Two Clades of Sibling Species of the Drosophila montium Species Subgroup
The Odysseus (OdsH) gene was duplicated from its ancestral neuron-expressed gene, unc-4, and then evolved very rapidly under strong positive Darwinian selection as a speciation gene causingExpand
Ephemeral Association Between Gene CG5762 and Hybrid Male Sterility in Drosophila Sibling Species
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The genetic associations between HMS and one of the genes, CG5762, a Drosophila-unique locus characterized by rapid sequence divergence within the genus, presumably driven by positive natural selection are dissected to conclude that CG 5762 is not a causative factor of HMS. Expand
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TLDR
The results show that the reciprocal F1 females of D. simulans and D. mauritiana hybridizations are fully fertile and in fact show a significant level of heterosis in the rate of oviposition but display reduced egg hatching in one direction, indicating the importance of maternal effects in the evolution of embryo inviability. Expand
Mechanisms Underlying Mammalian Hybrid Sterility in Two Feline Interspecies Models.
TLDR
The value of the interspecies feline model as a powerful tool for comparison to rodent models of HMS is supported, demonstrating unique aspects and potential commonalities that underpin mammalian reproductive isolation. Expand
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TLDR
The results from a natural hybrid zone suggest that the spermatogenesis of hybrid males may become disrupted despite little genetic divergence between the parental species. Expand
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