The Nonpsychotropic Cannabinoid Cannabidiol Modulates and Directly Activates Alpha-1 and Alpha-1-Beta Glycine Receptor Function

  title={The Nonpsychotropic Cannabinoid Cannabidiol Modulates and Directly Activates Alpha-1 and Alpha-1-Beta Glycine Receptor Function},
  author={J. Ahrens and R. Demir and M. Leuwer and J. de la Roche and K. Krampfl and N. Foadi and M. Karst and G. Haeseler},
  pages={217 - 222}
  • J. Ahrens, R. Demir, +5 authors G. Haeseler
  • Published 2009
  • Medicine, Chemistry
  • Pharmacology
  • Loss of inhibitory synaptic transmission within the dorsal horn of the spinal cord plays a key role in the development of chronic pain following inflammation or nerve injury. Inhibitory postsynaptic transmission in the adult spinal cord involves mainly glycine. Cannabidiol is a nonpsychotropic plant constituent of Cannabis sativa. As we hypothesized that non-CB receptor mechanisms of cannabidiol might contribute to its anti-inflammatory and neuroprotective effects, we investigated the… CONTINUE READING
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