The Nogo receptor, its ligands and axonal regeneration in the spinal cord; a review.

@article{Hunt2002TheNR,
  title={The Nogo receptor, its ligands and axonal regeneration in the spinal cord; a review.},
  author={David M Hunt and Robert S. Coffin and Patrick Anderson},
  journal={Journal of neurocytology},
  year={2002},
  volume={31 2},
  pages={93-120}
}
At least three proteins present in CNS myelin, Nogo, MAG and OMgp are capable of causing growth cone collapse and inhibiting neurite outgrowth in vitro. Surprisingly, Nogo and OMgp are also strongly expressed by many neurons (including neocortical projection cells). Nogo expression is increased by some cells at the borders of CNS lesion sites and by cells in injured peripheral nerves, but Nogo and CNS myelin are largely absent from spinal cord injury sites, which are none the less strongly… CONTINUE READING

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