The Nodes of Ranvier: Molecular Assembly and Maintenance.

@article{Rasband2015TheNO,
  title={The Nodes of Ranvier: Molecular Assembly and Maintenance.},
  author={Matthew N Rasband and Elior Peles},
  journal={Cold Spring Harbor perspectives in biology},
  year={2015},
  volume={8 3},
  pages={
          a020495
        }
}
Action potential (AP) propagation in myelinated nerves requires clustered voltage gated sodium and potassium channels. These channels must be specifically localized to nodes of Ranvier where the AP is regenerated. Several mechanisms have evolved to facilitate and ensure the correct assembly and stabilization of these essential axonal domains. This review highlights the current understanding of the axon intrinsic and glial extrinsic mechanisms that control the formation and maintenance of the… CONTINUE READING

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