The Nobel Chronicles

  title={The Nobel Chronicles},
  author={Tonse N. K. Raju},
  journal={The Lancet},
  • T. Raju
  • Published 18 September 1999
  • Philosophy
  • The Lancet
Dysbiosis From a Microbial and Host Perspective Relative to Oral Health and Disease
This review will emphasize the role that commensals and pathobionts play in their interaction with the immune status of the host, with a prediction that current “omic” technologies will allow researchers to better understand disease in the future. Expand
Immunotherapy for Pediatric Sarcomas
Early results from several trials indicate that this powerful strategy will eventually bear fruit, adding to the multimodal armament needed to cure high-risk malignancies. Expand
Monoclonal Gammopathies of Renal Significance: Renal Biopsy and Beyond
The present review deals with the implications of MGRS for renal function and prognosis, and the potential of tools, such as the renal biopsy, for assessing clinical risk and guiding therapy of the underlying condition. Expand
The Role of Organic Synthesis in the Emergence and Development of Antibody-Drug Conjugates as Targeted Cancer Therapies.
This Review is primarily focusing on the chemical synthesis aspects of the ADCs multidisciplinary research enterprise, covering oncological applications and a brief history of the emergence of the field of antibody-drug conjugates triggered more than a century ago by Paul Ehrlich's "magic bullet" concept. Expand
Immunomodulatory Functions of the Gastrointestinal Tract
This chapter is concerned with structure–function relationship of the lymphoid tissues of the GI tract and associated pathological conditions and the molecular mechanisms of functioning of GALT in normal and diseases are discussed. Expand
Prologue: The Term “Immunity” over the Course of Time
In the Prologue of Part I, the long way of the term “immunity” is briefly sketched, ranging from its first registered use in the context of health and disease 2000 years ago up to the description ofExpand
Recombinant Antibodies: Trends for Standardized Immunological Probes and Drugs
Recombinant antibodies are a unique source of biomolecules that are used as pharmacologic tools and may also contribute to a revival of immunodiagnostic and biomedical applications as yet unimagined. Expand
IgM predominance in autoimmune disease: genetics and gender.
Data is presented on clinical diseases with characteristic IgM abnormalities, including primary and secondary hyper IgM syndromes, autoimmune hemolytic anemia, cryoglobulinemia, primary biliary cirrhosis and multiple sclerosis and place the data in the perspective of the normal maturation of the immune response, including somatic mutation and genetic rearrangement. Expand