The NoCut Pathway Links Completion of Cytokinesis to Spindle Midzone Function to Prevent Chromosome Breakage

@article{Norden2006TheNP,
  title={The NoCut Pathway Links Completion of Cytokinesis to Spindle Midzone Function to Prevent Chromosome Breakage},
  author={Caren Norden and Manuel Mendoza and Jeroen Dobbelaere and Chitra V. Kotwaliwale and Sue Biggins and Yves Barral},
  journal={Cell},
  year={2006},
  volume={125},
  pages={85-98}
}
During anaphase, spindle elongation pulls sister chromatids apart until each pair is fully separated. In turn, cytokinesis cleaves the cell between the separated chromosomes. What ensures that cytokinesis proceeds only after that all chromosome arms are pulled out of the cleavage plane was unknown. Here, we show that a signaling pathway, which we call NoCut, delays the completion of cytokinesis in cells with spindle-midzone defects. NoCut depends on the Aurora kinase Ipl1 and the anillin… CONTINUE READING