The Nlrp3 inflammasome, IL-1β, and neutrophil recruitment are required for susceptibility to a nonhealing strain of Leishmania major in C57BL/6 mice.

@article{Charmoy2016TheNI,
  title={The Nlrp3 inflammasome, IL-1β, and neutrophil recruitment are required for susceptibility to a nonhealing strain of Leishmania major in C57BL/6 mice.},
  author={Melanie Charmoy and Benjamin P. Hurrell and Audrey Romano and Sang Hun Lee and Fl{\'a}via Lima Ribeiro-Gomes and Nicolas Riteau and Katrin D Mayer-Barber and Fabienne Tacchini-Cottier and David L Sacks},
  journal={European journal of immunology},
  year={2016},
  volume={46 4},
  pages={
          897-911
        }
}
Infection of C57BL/6 mice with most Leishmania major strains results in a healing lesion and clearance of parasites from the skin. Infection of C57BL/6 mice with the L. major Seidman strain (LmSd), isolated from a patient with chronic lesions, despite eliciting a strong Th1 response, results in a nonhealing lesion, poor parasite clearance, and complete destruction of the ear dermis. We show here that in comparison to a healing strain, LmSd elicited early upregulation of IL-1β mRNA and IL-1… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 26 CITATIONS

Drug Resistance in Leishmania Parasites

  • Springer International Publishing
  • 2018
VIEW 3 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 42 REFERENCES

Immunologic determinants of disease evolution in Published 2015. This article is a U.S. Government work and is in the public domain in the USA

H. Louzir, P. C. Melby, +4 authors K. Dellagi
  • 2015