The Nitric Oxide Prodrug V-PROLI/NO Inhibits Cellular Uptake of Proline.

@article{Hong2010TheNO,
  title={The Nitric Oxide Prodrug V-PROLI/NO Inhibits Cellular Uptake of Proline.},
  author={Sam Y Hong and Gregory L Borchert and Anna E. Maciag and Rahul S Nandurdikar and Joseph E. Saavedra and Larry K. Keefer and James Ming Phang and Harinath Chakrapani},
  journal={ACS medicinal chemistry letters},
  year={2010},
  volume={1 8},
  pages={386-389}
}
V-PYRRO/NO is a well studied nitric oxide (NO) prodrug which has been shown to protect human liver cells from arsenic, acetaminophen, and other toxic assaults in vivo. Its proline-based analogue, V-PROLI/NO, was designed to be a more biocompatible form that decomposes to the naturally occurring metabolites of proline, NO, and glycolaldehyde. Like V-PYRRO/NO, this cytochrome P450-activated prodrug was previously assumed to passively diffuse through the cellular membrane. Using (14)C-labeled… CONTINUE READING