The Nicotinic Acetylcholine Receptors of the Parasitic Nematode Ascaris suum: Formation of Two Distinct Drug Targets by Varying the Relative Expression Levels of Two Subunits

@inproceedings{Williamson2009TheNA,
  title={The Nicotinic Acetylcholine Receptors of the Parasitic Nematode Ascaris suum: Formation of Two Distinct Drug Targets by Varying the Relative Expression Levels of Two Subunits},
  author={Sally J.M. Williamson and Alan P Robertson and Laurence B. Brown and Tracey Williams and Debra J. Woods and Richard J. Martin and David B Sattelle and Adrian J Wolstenholme},
  booktitle={PLoS pathogens},
  year={2009}
}
Parasitic nematodes are of medical and veterinary importance, adversely affecting human health and animal welfare. Ascaris suum is a gastrointestinal parasite of pigs; in addition to its veterinary significance it is a good model of the human parasite Ascaris lumbricoides, estimated to infect approximately 1.4 billion people globally. Anthelmintic drugs are essential to control nematode parasites, and nicotinic acetylcholine receptors (nAChRs) on nerve and muscle are the targets of cholinergic… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 44 references

Molecular Basis of the Differential Sensitivity of Nematode and Mammalian Muscle to the Anthelmintic Agent Levamisole

  • D Rayes, MJ De Rosa, M Bartos, C Bouzat
  • J Biol Chem
  • 2004
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…