The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation.

@article{McClatchey1997TheNT,
  title={The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation.},
  author={Andrea I McClatchey and Ichiko Saotome and V Ramakrishnan Ramesh and James F. Gusella and Tyler 8 Jacks},
  journal={Genes & development},
  year={1997},
  volume={11 10},
  pages={1253-65}
}
The neurofibromatosis type II (NF2) tumor suppressor encodes a putative cytoskeletal associated protein, the loss of which leads to the development of Schwann cell tumors associated with NF2 in humans. The NF2 protein merlin belongs to the band 4.1 family of proteins that link membrane proteins to the cytoskeleton and are thought to be involved in dynamic cytoskeletal reorganization. Beyond its membership in this family, however, the function of merlin remains poorly understood. In order to… CONTINUE READING