The Next-Generation Sequencing Revolution and Its Impact on Genomics

@article{Koboldt2013TheNS,
  title={The Next-Generation Sequencing Revolution and Its Impact on Genomics},
  author={Daniel C. Koboldt and Karyn Meltz Steinberg and David E. Larson and Richard K. Wilson and Elaine R. Mardis},
  journal={Cell},
  year={2013},
  volume={155},
  pages={27-38}
}
Genomics is a relatively new scientific discipline, having DNA sequencing as its core technology. As technology has improved the cost and scale of genome characterization over sequencing's 40-year history, the scope of inquiry has commensurately broadened. Massively parallel sequencing has proven revolutionary, shifting the paradigm of genomics to address biological questions at a genome-wide scale. Sequencing now empowers clinical diagnostics and other aspects of medical care, including… CONTINUE READING

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