The Next-Generation Sequencing Revolution and Its Impact on Genomics

Abstract

Genomics is a relatively new scientific discipline, having DNA sequencing as its core technology. As technology has improved the cost and scale of genome characterization over sequencing's 40-year history, the scope of inquiry has commensurately broadened. Massively parallel sequencing has proven revolutionary, shifting the paradigm of genomics to address biological questions at a genome-wide scale. Sequencing now empowers clinical diagnostics and other aspects of medical care, including disease risk, therapeutic identification, and prenatal testing. This Review explores the current state of genomics in the massively parallel sequencing era.

DOI: 10.1016/j.cell.2013.09.006

Extracted Key Phrases

5 Figures and Tables

020040020132014201520162017
Citations per Year

1,406 Citations

Semantic Scholar estimates that this publication has 1,406 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Koboldt2013TheNS, title={The Next-Generation Sequencing Revolution and Its Impact on Genomics}, author={Daniel C. Koboldt and Karyn Meltz Steinberg and David E. Larson and Richard K. Wilson and Elaine R. Mardis}, journal={Cell}, year={2013}, volume={155}, pages={27-38} }