The New Low Calcemic Vitamin D Analog 22-Ene-25-Oxa-Vitamin D Prominently Ameliorates T Helper Cell Type 1-Mediated Colitis in Mice

  title={The New Low Calcemic Vitamin D Analog 22-Ene-25-Oxa-Vitamin D Prominently Ameliorates T Helper Cell Type 1-Mediated Colitis in Mice},
  author={Carolin Daniel and Heinfried H. Radeke and Nico A Sartory and Nadine Zahn and Ulrich Zuegel and Andreas Steinmeyer and J{\"u}rgen Stein},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={622 - 631}
  • C. DanielH. Radeke J. Stein
  • Published 1 November 2006
  • Medicine, Biology
  • Journal of Pharmacology and Experimental Therapeutics
In addition to its well defined role as a key regulator of calcium and bone metabolism, 1,25-dihydroxyvitamin D3 (calcitriol) has been established as a potent modulator of immune cell function. Still, because of the hypercalcemic toxicity occurring after systemic application of the parent compound, its clinical application as an immunosuppressant has been hampered. Recently, we described 22-ene-25-oxa-vitamin D (ZK156979) as a representative of a novel class of low calcemic vitamin D analogs… 

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