The New Immortalized Uroepithelial Cell Line HBLAK Contains Defined Genetic Aberrations Typical of Early Stage Urothelial Tumors

@inproceedings{Hoffmann2016TheNI,
  title={The New Immortalized Uroepithelial Cell Line HBLAK Contains Defined Genetic Aberrations Typical of Early Stage Urothelial Tumors},
  author={Mich{\`e}le J Hoffmann and Evangelia A. Koutsogiannouli and Margaretha A Skowron and Maria Pinkerneil and Guenter Niegisch and Artur Brandt and Stefanie Stepanow and Harald Rieder and Wolfgang A. Schulz},
  booktitle={Bladder cancer},
  year={2016}
}
Background: Cell culture models of normal urothelial cells are important for studying differentiation, disease mechanisms and anticancer drug development. Beyond primary cultures with their limitations in lifespan, interindividual heterogeneity and supply, few conditionally immortalized cell lines with limited applicability due to partial transformation or impaired differentiation capacity are available. We describe characteristics of the new spontaneously immortalized cell line HBLAK derived… CONTINUE READING