The Neutrophil

  title={The Neutrophil},
  author={David H. Dockrell and Emmet Mcgrath and M. K. Whyte and Ian Sabroe},
  journal={Immunology of Fungal Infections},
  pages={51 - 73}
The neutrophil provides a crucial defence against fungal infections. This numerous phagocyte is recruited rapidly to sites of infection, where it detects pathogens through a range of pathogen-recognition receptors. Phagocytosis and the generation of a range of microbicidal molecules neutralises the pathogen, following which neutrophil death by apoptosis triggers an injury-limiting resolution process facilitating the restoration of normal tissue architecture 



Chemokines--chemotactic cytokines that mediate inflammation.

  • A. Luster
  • Biology
    The New England journal of medicine
  • 1998
This review introduces the burgeoning family of cytokines, with special emphasis on their role in the pathophysiology of disease and their potential as targets for therapy.

TLRs Govern Neutrophil Activity in Aspergillosis1

The ability of selected individual TLRs to restore antifungal functions in defective PMNs suggests that the coordinated outputs of activation of multiple TLRs may contribute to PMN function in aspergillosis.

The C5a chemoattractant receptor mediates mucosal defence to infection

It is concluded that the C5a receptor has a non-redundant function, and is required for mucosal host defence in the lung in mice challenged with sub-lethal inocula of Pseudomonas aeruginosa.

Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences.

The task is to understand and explain these diametrically opposed reactions to stimulation of the same receptors, which when microbial organisms or their products are engulfed via these receptors, inflammation results, and in many cases, acquired immunity is stimulated.

Toll-like receptor signalling

Rapid progress that has recently improved the understanding of the molecular mechanisms that mediate TLR signalling is reviewed.

Death receptors: signaling and modulation.

Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique

Phagocytosis of medically important yeasts by polymorphonuclear leukocytes

Phagocytosis of C. albicans by polymorphonuclear leukocytes is comparable to that of species other than C.Albicans but is significantly greater than that of the basidiomycetous yeasts T. beigelii and C. neoformans.

Pyocyanin Production by Pseudomonas aeruginosa Induces Neutrophil Apoptosis and Impairs Neutrophil-Mediated Host Defenses In Vivo1

Clearance of neutrophils from inflamed sites is critical for resolution of inflammation, but pathogen-driven neutrophil apoptosis can impair host defenses. We previously showed that pyocyanin, a

Granulocyte apoptosis and inflammatory disease.

  • C. Haslett
  • Biology, Medicine
    British medical bulletin
  • 1997
The apoptotic mechanisms available in neutrophil and eosinophil granulocytes provide opportunities for the selective induction of apoptosis in specific inflammatory cells in what may represent novel therapeutic approaches to inflammatory disease.

Participation of complement in the phagocytosis of the conidia of Aspergillus fumigatus by human polymorphonuclear cells.

Phagocytosis experiments in the presence of plasma treated in various ways to inhibit the complement pathways demonstrated that optimal association was dependent on an active alternative complement pathway.