The Neurotensin Agonist PD149163 Increases Fos Expression in the Prefrontal Cortex of the Rat

@article{Petrie2004TheNA,
  title={The Neurotensin Agonist PD149163 Increases Fos Expression in the Prefrontal Cortex of the Rat},
  author={Kimberly A Petrie and Michael Bubser and Cheryl D Casey and Michael Duff Davis and Bryan L. Roth and Ariel Y. Deutch},
  journal={Neuropsychopharmacology},
  year={2004},
  volume={29},
  pages={1878-1888}
}
Dopaminergic axons innervating the prefrontal cortex (PFC) target both pyramidal cells and GABAergic interneurons. Many of these dopamine (DA) axons in the rat coexpress the peptide neurotransmitter neurotensin. Previous electrophysiological data have suggested that neurotensin activates GABAergic interneurons in the PFC. Activation of D2-like DA receptors increases extracellular GABA levels in the PFC, as opposed to the striatum, where D2 receptor activation inhibits GABAergic neurons. Because… CONTINUE READING
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