The Neurosteroidogenic Enzyme 5α-Reductase Mediates Psychotic-Like Complications of Sleep Deprivation.

@article{Frau2017TheNE,
  title={The Neurosteroidogenic Enzyme 5α-Reductase Mediates Psychotic-Like Complications of Sleep Deprivation.},
  author={Roberto Frau and Valentina Bini and Alessio Soggiu and Simona Scheggi and Alessandra Pardu and Silvia Fanni and Paola Roncada and Monica Puligheddu and Francesco Marrosu and Donatella Caruso and Paola Devoto and Marco Bortolato},
  journal={Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year={2017},
  volume={42 11},
  pages={
          2196-2205
        }
}
Acute sleep deprivation (SD) can trigger or exacerbate psychosis- and mania-related symptoms; the neurobiological basis of these complications, however, remains elusive. Given the extensive involvement of neuroactive steroids in psychopathology, we hypothesized that the behavioral complications of SD may be contributed by 5α-reductase (5αR), the rate-limiting enzyme in the conversion of progesterone into the neurosteroid allopregnanolone. We first tested whether rats exposed to SD may exhibit… CONTINUE READING