The Neuroprotective Effect of Thalidomide against Ischemia through the Cereblon-mediated Repression of AMPK Activity

@inproceedings{Sawamura2018TheNE,
  title={The Neuroprotective Effect of Thalidomide against Ischemia through the Cereblon-mediated Repression of AMPK Activity},
  author={Naoya Sawamura and Mariko Yamada and Miku Fujiwara and Haruka Yamada and Hideki Hayashi and Norio Takagi and Toru Asahi},
  booktitle={Scientific Reports},
  year={2018}
}
Thalidomide was originally used as a sedative and found to be a teratogen, but now thalidomide and its derivatives are widely used to treat haematologic malignancies. Accumulated evidence suggests that thalidomide suppresses nerve cell death in neurologic model mice. However, detailed molecular mechanisms are unknown. Here we examined the molecular mechanism of thalidomide’s neuroprotective effects, focusing on its target protein, cereblon (CRBN), and its binding protein, AMP-activated protein… CONTINUE READING
0 Citations
41 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 41 references

The Neuroprotection of Liraglutide Against Ischaemia-induced Apoptosis through the Activation of the PI3K/AKT and MAPKPathways

  • H Zhu
  • Scientific reports
  • 2016

Similar Papers

Loading similar papers…