The Neuroprotection of Liraglutide Against Ischaemia-induced Apoptosis through the Activation of the PI3K/AKT and MAPK Pathways

@inproceedings{Zhu2016TheNO,
  title={The Neuroprotection of Liraglutide Against Ischaemia-induced Apoptosis through the Activation of the PI3K/AKT and MAPK Pathways},
  author={Huili Zhu and Yusheng Zhang and Zhongshan Shi and Dan Lu and Tingting Li and Yan Ding and Yiwen Ruan and Anding Xu},
  booktitle={Scientific reports},
  year={2016}
}
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that increases glucose-dependent insulin secretion to reduce the glucose level. Liraglutide, a long-acting GLP-1 analogue, has been found to have neuroprotective action in various experimental models. However, the protective mechanisms of liraglutide in ischaemic stroke remain unclear. Here, we demonstrated that liraglutide significantly decreased the infarct volume, improved neurologic deficits, and lowered stress-related hyperglycaemia… CONTINUE READING
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The authors declare no competing financial interests

T. R. Doeppner, B. Kaltwasser, +21 authors approved the final manuscript. Additional Information Compe interests
  • How to cite this article: Zhu, H. et al. The Neuroprotection of Liraglutide against Ischaemia-induced Apoptosis through the Activation of the PI3K/AKT and MAPK Pathways. Sci. Rep. 6, 26859; doi: 10.1038/srep26859
  • 2016

Effects of Exendin-4 on bone marrow mesenchymal stem cell proliferation, migration and apoptosis in vitro

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Global and regional burden of first - ever ischaemic and haemorrhagic stroke during 1990 – 2010 : findings from the Global Burden of Disease Study 2010

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  • Lancet Glob Health
  • 2013

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