The Neuronal Channel NALCN Contributes Resting Sodium Permeability and Is Required for Normal Respiratory Rhythm

@article{Lu2007TheNC,
  title={The Neuronal Channel NALCN Contributes Resting Sodium Permeability and Is Required for Normal Respiratory Rhythm},
  author={B. Lu and Yanhua Su and Sudipto Das and Jin Liu and Jingsheng Xia and Dejian Ren},
  journal={Cell},
  year={2007},
  volume={129},
  pages={371-383}
}
Sodium plays a key role in determining the basal excitability of the nervous systems through the resting "leak" Na(+) permeabilities, but the molecular identities of the TTX- and Cs(+)-resistant Na(+) leak conductance are totally unknown. [...] Key Result NALCN mutant mice have a severely disrupted respiratory rhythm and die within 24 hours of birth. Brain stem-spinal cord recordings reveal reduced neuronal firing.Expand
Roles of the ion channel NALCN in neuronal excitability control
Structure of the human sodium leak channel NALCN
Nalcn Is a “Leak” Sodium Channel That Regulates Excitability of Brainstem Chemosensory Neurons and Breathing
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