The Neuronal Adaptor Protein X 11 Reduces A Levels in the Brains of Alzheimer ’ s APPswe Tg 2576 Transgenic Mice *

@inproceedings{Lee2003TheNA,
  title={The Neuronal Adaptor Protein X 11 Reduces A Levels in the Brains of Alzheimer ’ s APPswe Tg 2576 Transgenic Mice *},
  author={Ju-Hyun Lee and K F Lau and Michael S. Perkinton and Claire L. Standen and Stephen J. A. Shemilt and Luc Mercken and Jonathan D Cooper and Declan M McLoughlin and Christopher Charles John Miller},
  year={2003}
}
Increased production and deposition of the 40–42amino acid -amyloid peptide (A ) is believed to be central to the pathogenesis of Alzheimer’s disease. A is derived from the amyloid precursor protein (APP), but the mechanisms that regulate APP processing to produce A are not fully understood. X11 (also known as munc-18-interacting protein-1 (Mint1)) is a neuronal adaptor protein that binds APP and modulates APP processing in transfected non-neuronal cells. To investigate the in vivo effect of… CONTINUE READING
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Reduces A Levels in the Brains of Transgenic Mice 47029 at IR eL (T rnity C olege D ulin), on S etem er 17

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