The Neuron-specific Chromatin Regulatory Subunit BAF53b is Necessary for Synaptic Plasticity and Memory

@inproceedings{VogelCiernia2013TheNC,
  title={The Neuron-specific Chromatin Regulatory Subunit BAF53b is Necessary for Synaptic Plasticity and Memory},
  author={Annie Vogel-Ciernia and Dina P Matheos and Ruth M. Barrett and Enik{\"o} A. Kram{\'a}r and Soraya Azzawi and Y Chen and Christophe N. Magnan and Michael D. Zeller and Angelina Sylvain and Jakob Haettig and Yousheng Jia and Anthony Tran and Richard T Dang and Rebecca J. Post and Meredith A Chabrier and Alex H. Babayan and Jiang I. Wu and Gerald R Crabtree and Pierre Baldi and Tallie Z. Baram and Gary Lynch and Marcelo Wood},
  booktitle={Nature Neuroscience},
  year={2013}
}
Recent exome sequencing studies have implicated polymorphic Brg1-Associated Factor (BAF) complexes (mammalian SWI/SNF chromatin remodeling complexes) in several human intellectual disabilities and cognitive disorders. However, it is currently unknown how mutations in BAF complexes result in impaired cognitive function. Postmitotic neurons express a neuron-specific assembly, nBAF, characterized by the neuron-specific subunit BAF53b. Mice harboring selective genetic manipulations of BAF53b have… CONTINUE READING