The Neurocognitive Signature of Psychotic Bipolar Disorder

@article{Glahn2007TheNS,
  title={The Neurocognitive Signature of Psychotic Bipolar Disorder},
  author={David C. Glahn and Carrie E. Bearden and Marcela Barguil and Jennifer A Barrett and Abraham Reichenberg and Charles L. Bowden and Jair C. Soares and Dawn I Velligan},
  journal={Biological Psychiatry},
  year={2007},
  volume={62},
  pages={910-916}
}
BACKGROUND Psychotic bipolar disorder may represent a neurobiologically distinct subgroup of bipolar affective illness. We sought to ascertain the profile of cognitive impairment in patients with bipolar disorder and to determine whether a distinct profile of cognitive deficits characterizes bipolar patients with a history of psychosis. METHODS Sixty-nine outpatients with bipolar I disorder (34 with a history of psychotic symptoms and 35 with no history of psychosis) and 35 healthy comparison… Expand
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References

SHOWING 1-10 OF 38 REFERENCES
Differential working memory impairment in bipolar disorder and schizophrenia: effects of lifetime history of psychosis.
TLDR
Backward digit span performance is comparable in bipolar disorder and schizophrenia, and may be an appropriate endophenotypic marker that cuts across diagnostic categories, while spatial working memory performance clearly distinguishes non-psychotic bipolar disorder patients from patients with functional psychosis. Expand
Psychosis in bipolar disorder: phenomenology and impact on morbidity and course of illness.
TLDR
The phenomenology and prevalence of mood-congruent and mood-incongruent psychotic symptoms in 352 patients with bipolar I disorder participating in the Stanley Foundation Bipolar Treatment Network supported the lack of diagnostic specificity of any one type of psychotic symptom. Expand
Neurocognitive impairment in euthymic patients with bipolar affective disorder
TLDR
Neurocognitive impairment persists in patients whose bipolar disorder is in remission and may represent a trait abnormality and be a marker of underlying neurobiological dysfunction. Expand
Neuropsychology of bipolar disorder: a review.
TLDR
The profile of cognitive deficits in BD at different phases of the illness is described to determine whether it is different from that of schizophrenia and unipolar (UP) depression. Expand
A comparative profile analysis of neuropsychological functioning in patients with schizophrenia and bipolar psychoses
TLDR
It is indicated that patients with schizophrenia had a more severe impairment than patients with bipolar psychoses, and further research is required to determine whether similar mechanisms underly the neurocognitive deficits in these disorders. Expand
Sources of declarative memory impairment in bipolar disorder: mnemonic processes and clinical features.
TLDR
Declarative memory impairments in bipolar patients are consistent with deficits in learning, but do not seem to be related to different organizational strategies during learning, and do not appear to be secondary to clinical state, but rather may be associated with the underlying pathophysiology of the illness. Expand
Cognitive function across manic or hypomanic, depressed, and euthymic states in bipolar disorder.
TLDR
A poorer performance was observed in all bipolar groups regarding executive function and verbal memory in relation to the healthy comparison subjects, and cognitive difficulties, especially related to verbal memory, may help explain the impairment regarding daily functioning, even during remission. Expand
Contrasts between patients with affective disorders and patients with schizophrenia on a neuropsychological test battery.
TLDR
It is suggested that patients with schizophrenia perform systematically worse on cognitive measures than patients with affective disorders, which is consistent with their generally poorer outcome. Expand
Association of symptoms and executive function in schizophrenia and bipolar disorder
TLDR
Executive dysfunction in patients with psychotic disorders may be more related to their symptom profile than their diagnosis, and a statistical comparison of the associations of 'diagnosis' and the 'excess-deficiency' dimension with executive function revealed a trend for a greater association of the latter with two measures of performance accuracy. Expand
Dissociable mechanisms for memory impairment in bipolar disorder and schizophrenia.
TLDR
Evidence of impairment in detection of novel stimuli that is unique to bipolar disorder suggests that, while the absolute level of cognitive dysfunction is less severe in bipolar disorder as compared to schizophrenia, subtle disruptions in memory are present. Expand
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