The Neurocognitive Signature of Psychotic Bipolar Disorder

  title={The Neurocognitive Signature of Psychotic Bipolar Disorder},
  author={David C. Glahn and Carrie E. Bearden and Marcela Barguil and Jennifer A Barrett and Abraham Reichenberg and Charles L. Bowden and Jair C. Soares and Dawn I Velligan},
  journal={Biological Psychiatry},

Neuropsychological status of bipolar I disorder: impact of psychosis

‘Psychotic’ and ‘non-psychotic” subtypes of bipolar disorder may lie on a nosological continuum that is most clearly defined by verbal memory impairment.

Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic group.

The findings suggest that neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders is determined more by history of psychosis than by Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) diagnostic category or subtype, supporting a more dimensional approach in future diagnostic systems.

Effect of psychotic symptoms on cognitive impairment in patients with bipolar disorder

The study findings, at least with respect to cognitive function, suggest that BD with psychotic symptoms may not be a categorically distinct subtype of BD, and cognitive functions need to be assessed in all patients with BD, regardless of psychotic symptoms.

Investigating the association between neurocognition and psychosis in bipolar disorder: further evidence for the overlap with schizophrenia.

The finding of similar psychosis-cognition associations in bipolar disorder as implied by the two pathways leading to non Affective psychotic disorders suggests that this model might be extended to the continuum spanning affective and nonaffective psychosis.

Shared and Distinct Neurocognitive Endophenotypes of Schizophrenia and Psychotic Bipolar Disorder

  • Dohoon KimJiwoo KimT. KooH. YunS. Won
  • Psychology, Medicine
    Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
  • 2015
Findings suggest that a deficit in working memory could be a shared endophenotype of genetic vulnerability to schizophrenia and psychotic bipolar disorder, and verbal fluencyCould be a candidate endophenotypes for schizophrenia specifically.

Psychosocial function in schizophrenia and bipolar disorder: Relationship to neurocognition and clinical symptoms

Despite differences in neurocognition and psychosocial function, groups showed the same pattern in prediction of functioning irrespective of DSM-IV or clinical definition.

Mood congruence phenomenon in acutely symptomatic mania bipolar I disorder patients with and without psychotic symptoms

Psychotic and nonpsychotic mania BD-I patients showed mood congruence phenomenon in a verbal memory task with positive tone in relation to the healthy group suggesting a purer manifestation of the disease.

Working memory predicts presence of auditory verbal hallucinations in schizophrenia and bipolar disorder with psychosis

The findings of this study—the first, to the authors' knowledge, to compare the relationship between AVHs and MATRICS domains across schizophrenia and bipolar disorder with psychosis—support theories that deficits in WM underly the genesis ofAVHs.



Differential working memory impairment in bipolar disorder and schizophrenia: effects of lifetime history of psychosis.

Backward digit span performance is comparable in bipolar disorder and schizophrenia, and may be an appropriate endophenotypic marker that cuts across diagnostic categories, while spatial working memory performance clearly distinguishes non-psychotic bipolar disorder patients from patients with functional psychosis.

Neurocognitive impairment in euthymic patients with bipolar affective disorder

Neurocognitive impairment persists in patients whose bipolar disorder is in remission and may represent a trait abnormality and be a marker of underlying neurobiological dysfunction.

Neuropsychology of bipolar disorder: a review.

Cognitive function across manic or hypomanic, depressed, and euthymic states in bipolar disorder.

A poorer performance was observed in all bipolar groups regarding executive function and verbal memory in relation to the healthy comparison subjects, and cognitive difficulties, especially related to verbal memory, may help explain the impairment regarding daily functioning, even during remission.

Contrasts between patients with affective disorders and patients with schizophrenia on a neuropsychological test battery.

It is suggested that patients with schizophrenia perform systematically worse on cognitive measures than patients with affective disorders, which is consistent with their generally poorer outcome.

The familial aggregation of psychotic symptoms in bipolar disorder pedigrees.

Psychotic bipolar disorder may delineate a subtype of value for genetic and biological investigations, and families with this subtype should be used to search for linkage in chromosomal regions 10p12-13, 13q32, 18p11.2, and 22q11- 13, where susceptibility genes common to bipolar disorder and schizophrenia may reside.