The Neurobiology of Trust

  title={The Neurobiology of Trust},
  author={Paul J. Zak and Robert Kurzban and William T. Matzner},
  journal={Annals of the New York Academy of Sciences},
Abstract: This is the first report that endogenous oxytocin in humans is related to social behaviors, which is consistent with a large animal literature. Subjects are put into a social dilemma in which absent communication, cooperative behavior can benefit both parties randomly assigned to a dyad. The dilemma arises because one participant must make a monetary sacrifice to signal the degree of trust in the other before the other's behavioral response is known. We show that receipt of a signal… Expand
Neuroeconomics and International Studies: A New Understanding of Trust
Nearly all political choices depend on trust—or a lack thereof. In world politics, successful negotiations, arms agreements, and deterrence postures all depend on trust. This paper reviews recentExpand
Oxytocin infusion increases charitable donations regardless of monetary resources
This is the first study showing that OT increases generosity in unilateral exchanges directed toward philanthropic social institutions, as opposed to immediate benefits directed at individuals or groups. Expand
Oxytocin and cooperation under conditions of uncertainty: The modulating role of incentives and social information
Investigating how OT interacts with two well-studied determinants of cooperative behavior: incentives and social information found social information appears to be crucial for OT to boost cooperative expectations in an interdependent social interaction that provides incentives to cooperate. Expand
Neurochemistry of Prosocial Decision Making: The Role of Dopamine, Serotonin, and Oxytocin
Neurotransmitters impact behavior by altering the signal transduction between neurons in the central nervous system, thereby channeling information that will affect how decisions are framed. In thisExpand
Trust – a Subject for Social Neuroscience?
The term trust has its roots in psychology and the social sciences, it stands for a complex construct having a high relevance in certain domains, ranging from everyday-live issues over sociology andExpand
Test and Evaluation of TRUST: Tools for Recognizing Useful Signals of Trustworthiness
Abstract : This study focuses on the measurement of trustworthiness. The report focuses on testing, research and evaluation of a new research method for measuring and requiring trust betweenExpand
Neural Substrates of Decision-Making in Economic Games
In economic experiments decisions often differ from game-theoretic predictions. Why are people generous in one-shot ultimatum games with strangers? Is there a benefit to generosity toward strangers?Expand
Massage increases oxytocin and reduces adrenocorticotropin hormone in humans.
This study is the first using a large sample of mixed gender that demonstrates that massage increases OT and decreases ACTH, NO, and BE, and may help explain the mechanisms through which social connections reduce morbidity and mortality. Expand
Knowing When to Trust Others: An ERP Study of Decision Making After Receiving Information from Unknown People
Reaction times and event-related brain potentials suggest that even when people behave as if they trust information, they consider communicative efforts of individuals whose interests are aligned with their own to be slightly more informative than those of individuals who are made trustworthy by an institution, such as a penalty for lying. Expand
Values and Value: Moral Economics
This chapter will survey neuroscientific research and discuss recent experiments from my lab on the physiologic basis for interpersonal decision-making to support the follow thesis: most people, mostExpand


Trust, Reciprocity, and Social History
Abstract We designed an experiment to study trust and reciprocity in an investment setting. This design controls for alternative explanations of behavior including repeat game reputation effects,Expand
The Neurobiology of Social Affiliation and Pair Bonding
Positive social interactions, including affiliations and social bonds, dominate the behavioral repertoire of humans and many higher vertebrates. Pair bonding is an evolved trait and may play aExpand
The social deficits of the oxytocin knockout mouse
The development of transgenic mice with specific deficits in social memory represents a promising approach to examine the cellular and neural systems of social cognition. Expand
The neurobiology of attachment
Over the past decade, studies in a range of vertebrates, including humans, have begun to address the neural basis of attachment at a molecular, cellular and systems level. Expand
Oxytocin Receptor Distribution Reflects Social Organization in Monogamous and Polygamous Voles
  • L. Shapiro, T. Insel
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1992
It is demonstrated that species from the genus Microtus (voles) selected for differences in social affiliation show contrasting patterns of oxytocin receptor expression in brain, and it is suggested that variable expression of the oxytocIn receptor in brain may be an important mechanism in evolution of species-typical Differences in social bonding and affiliative behavior. Expand
Lonely traits and concomitant physiological processes: the MacArthur social neuroscience studies.
  • J. Cacioppo, J. M. Ernst, +9 authors G. Berntson
  • Psychology, Medicine
  • International journal of psychophysiology : official journal of the International Organization of Psychophysiology
  • 2000
Satisfying social relationships were associated with more positive outlooks on life, more secure attachments and interactions with others, more autonomic activation when confronting acute psychological challenges, and more efficient restorative behaviors. Expand
Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress
Oxytocin seems to enhance the buffering effect of social support on stress responsiveness, concur with data from animal research suggesting an important role of oxytocin as an underlying biological mechanism for stress-protective effects of positive social interactions. Expand
An estrogen-dependent four-gene micronet regulating social recognition: A study with oxytocin and estrogen receptor-α and -β knockout mice
A four-gene micronet is proposed, which links hypothalamic and limbic forebrain neurons in the estrogen control over the OT regulation of social recognition, and suggests the involvement in social recognition of the four genes coding for ER-α, ER-β, OT, and the OT receptor. Expand
An estrogen-dependent four-gene micronet regulating social recognition: a study with oxytocin and estrogen receptor-alpha and -beta knockout mice.
A four-gene micronet is proposed, which links hypothalamic and limbic forebrain neurons in the estrogen control over the OT regulation of social recognition, and suggests the involvement in social recognition of the four genes coding for ER-alpha, ER-beta, OT, and the OT receptor. Expand
Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin.
  • C. Pedersen, A. Prange
  • Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1979
Elevated or recently elevated levels of estrogen may be necessary for the induction of full maternal behavior by oxytocin, functions related to parturition and nuturing in virgin female rats. Expand