The Neural RNA-Binding Protein Musashi1 Translationally Regulates Mammalian numb Gene Expression by Interacting with Its mRNA

@article{Imai2001TheNR,
  title={The Neural RNA-Binding Protein Musashi1 Translationally Regulates Mammalian numb Gene Expression by Interacting with Its mRNA},
  author={T. Imai and A. Tokunaga and T. Yoshida and M. Hashimoto and K. Mikoshiba and G. Weinmaster and M. Nakafuku and H. Okano},
  journal={Molecular and Cellular Biology},
  year={2001},
  volume={21},
  pages={3888 - 3900}
}
  • T. Imai, A. Tokunaga, +5 authors H. Okano
  • Published 2001
  • Biology, Medicine
  • Molecular and Cellular Biology
  • ABSTRACT Musashi1 (Msi1) is an RNA-binding protein that is highly expressed in neural progenitor cells, including neural stem cells. In this study, the RNA-binding sequences for Msi1 were determined by in vitro selection using a pool of degenerate 50-mer sequences. All of the selected RNA species contained repeats of (G/A)U n AGU (n = 1 to 3) sequences which were essential for Msi1 binding. These consensus elements were identified in some neural mRNAs. One of these, mammaliannumb (m-numb… CONTINUE READING
    403 Citations
    Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP
    • 165
    • PDF
    The Oncogenic RNA-Binding Protein Musashi1 Is Regulated by HuR via mRNA Translation and Stability in Glioblastoma Cells
    • 56
    • PDF
    A role for the ELAV RNA-binding proteins in neural stem cells: stabilization of Msi1 mRNA
    • 74
    • Highly Influenced
    • PDF
    Characterization of the RNA-binding protein Musashi1 in zebrafish
    • 16
    Function of RNA-binding protein Musashi-1 in stem cells.
    • 335
    cDNA cloning and characterization of Drb1, a new member of RRM-type neural RNA-binding protein.
    • 22

    References

    SHOWING 1-10 OF 92 REFERENCES
    Mammalian ELAV-like neuronal RNA-binding proteins HuB and HuC promote neuronal development in both the central and the peripheral nervous systems.
    • W. Akamatsu, H. Okano, +7 authors H. Okano
    • Medicine, Biology
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1999
    • 223
    • PDF
    Mouse-Musashi-1, a neural RNA-binding protein highly enriched in the mammalian CNS stem cell.
    • 496
    Identification of HuR as a protein implicated in AUUUA‐mediated mRNA decay
    • 311
    • PDF
    Characterization of Four Mammalian Numb Protein Isoforms
    • 113
    • PDF
    The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo.
    • 247
    • PDF